Catastrophe and Cooperation

Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown.

Chromosomal instability (CIN) is a hallmark of solid tumor biology and is implicated in carcinogenesis. Preferentially eliminating malignant cells by targeting CIN and aneuploidy is an attractive antineoplastic strategy. We previously reported that CDK2 antagonism causes lung cancer cells to undergo anaphase catastrophe and apoptosis through inhibition of phosphorylation of the centrosomal prot...

Do Firms Manage Catastrophe and Non-Catastrophe Risks Differently?

Recent disasters and historical insurance payouts have triggered renewed interest in how firms manage their left-tail exposure. Using a unique dataset of fully described insurance policies purchased by large U.S. firms, we provide the first consistent estimates of premium elasticity of corporate demand for insurance for both catastrophe and noncatastrophe risks. We do so by combining this datas...

M/M/1 Feedback Queue Subject to Catastrophe and Repairment

‎In this paper‎, ‎an M/M/1 queue with instantaneous Bernoulli feedback is studied in the event of server failure‎, ‎the catastrophe occurs and after repair‎, ‎it starts to work again‎. ‎The transient response for the probability function of the system size is presented‎. ‎The steady state analysis of system size probabilities and some performance measures of system are provided‎. ‎Then the resu...

Microtubule catastrophe and rescue.

Microtubules are long cylindrical polymers composed of tubulin subunits. In cells, microtubules play an essential role in architecture and motility. For example, microtubules give shape to cells, serve as intracellular transport tracks, and act as key elements in important cellular structures such as axonemes and mitotic spindles. To accomplish these varied functions, networks of microtubules i...

Dialectics and Catastrophe